ANTIMICROBIAL AND DNA CLEAVAGE STUDIES OF TRINUCLEAR Cu(II), Ni(II) AND Mn(II) SCHIFF BASE COMPLEXES
نویسندگان
چکیده
Complexes of Cu(II), Ni(II) and Mn(II) containing a novel homotrinuclear Schiff base metal complexes were synthesized by using 2,3-pentanedione, p-phenylenediamine and 2-aminobenzaldehyde. The complexes of the type [LM 3 Cl 6 ]. The characterization and nature of bonding of the trinuclear complexes have been deduced from elemental analysis, molar conductivity, FT-IR, UV-visible, magnetic and EPR studies. The pUC18 DNA cleavage study was monitored by gel electrophoresis method. The results suggest that trinuclear Cu(II), Ni(II) and Mn(II) complexes cleaves pUC18 DNA in presence of the oxidant H 2 O 2. The in vitro antimicrobial activity of the synthesized complexes have been tested against the Gram negative bacteria like Klebsiella pneumoniae, Escherichia coli and Gram positive bacteria Staphylococcus aureus. The trinuclear Schiff base complexes were found to be more active when compared to Standard Streptomycin.
منابع مشابه
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